Are you Negative Blood Donor in India , Please Join RareBloodGroups.Org

Are you Negative Blood Donor in India , Please Join RareBloodGroups.Org

PLEASE VISIT WWW.RAREBLOODGROUPS.ORG

Imagine some unfortunate disaster happen here in the city like Earth Quakes in Gujrat and Kashmir or any other . Are we ready of face the same .


We have started a new support group for RH Negative Blood Types & Rare Blood Groups.


Rare Blood is just like all other Blood, and will not cause you any problem at all unless you need a transfusion.

The goal of the our new website RareBloodGroups.Org is to maintain an up-to-date registry of all donors with rare blood types i.e AB Negative Blood , B Negative Blood, O Negative Blood, A Negative Blood and Bombay Blood Group so that any patient in need can quickly be transfused with blood that is safe for him or her.

Please visit this website at


http://www.rarebloodgroups.org




Marjor Districts and Towns where we are looking for Rh Negative Blood Donors i.e AB Negative Blood , B Negative Blood, O Negative Blood, A Negative Blood and Bombay Blood Group ( Rare Blood Groups )



Negative Blood Donor in Anjaw , Negative Blood Donor in Changlang , Negative Blood Donor in Dibang Valley ,Negative Blood Donor in East Kameng ,Negative Blood Donor in ,East Siang , Negative Blood Donor in Kurung Kumey , Lohit Lower , Negative Blood Donor in Dibang Valley Lower , Negative Blood Donor in Subansiri Papum Pare , Negative Blood Donor in Tawang Tirap ,Negative Blood Donor in Bagalkot ,Negative Blood Donor in Bangalore ,Negative Blood Donor in Bangalore ,Negative Blood Donor in Rural Belgaum ,Negative Blood Donor in Bellary ,Negative Blood Donor in Bidar ,Negative Blood Donor in Bijapur , Negative Blood Donor in Chamrajnagar, Negative Blood Donor in Chickmagalur, Negative Blood Donor in Chikballapur ,Negative Blood Donor in Chitradurga ,Negative Blood Donor in Dakshina ,Negative Blood Donor in Kannada ,Negative Blood Donor in Davangere ,Negative Blood Donor in Dharwad ,Negative Blood Donor in Gadag ,Negative Blood Donor in Gulbarga ,Negative Blood Donor in Hassan ,Negative Blood Donor in Haveri ,Negative Blood Donor in Kodagu ,Negative Blood Donor in Kolar Koppal, Negative Blood Donor in Mandya ,Negative Blood Donor in Mysore ,Negative Blood Donor in Raichur, Negative Blood Donor in Shimoga ,Negative Blood Donor in Tumkur ,Negative Blood Donor in Udupi ,Negative Blood Donor in Uttara Kannada ,
Negative Blood Donor in Agra , Negative Blood Donor in Aligarh, Negative Blood Donor in Allahabad , Negative Blood Donor in Ambedkar Nagar, Negative Blood Donor in Auraiya, Negative Blood Donor in Azamgarh, Negative Blood Donor in Bagpat, Negative Blood Donor in Bahraich , Negative Blood Donor in Ballia, Negative Blood Donor in Balrampur, Negative Blood Donor in Banda, Negative Blood Donor in Barabanki, Negative Blood Donor in Bareilly, Negative Blood Donor in Basti, Negative Blood Donor in Bijnor, Negative Blood Donor in Budaun , Negative Blood Donor in Bulandshahr, Negative Blood Donor in Chandauli, Negative Blood Donor in Chitrakoot, Negative Blood Donor in Deoria , Negative Blood Donor in Etah, Negative Blood Donor in Etawah , Negative Blood Donor in Faizabad , Negative Blood Donor in Farrukhabad, Negative Blood Donor in Fatehpur , Negative Blood Donor in Firozabad , Negative Blood Donor in Gautam Buddha Nagar, Negative Blood Donor in ghaziabad, Negative Blood Donor in Ghazipur, Negative Blood Donor in Gonda , Negative Blood Donor in Gorakhpur, Negative Blood Donor in Hamirpur, Negative Blood Donor in Hardoi, Negative Blood Donor in Hathras, Negative Blood Donor in Jalaun, Jaunpur, Negative Blood Donor in Jhansi , Negative Blood Donor in Jyotiba ,Phule Nagar, Kannauj , Negative Blood Donor in Kanpur Dehat, Negative Blood Donor in Kanpur Nagar, Negative Blood Donor in Kaushambi , Negative Blood Donor in Kheri , Negative Blood Donor in Kushinagar, Negative Blood Donor in Lalitpur, Negative Blood Donor in Lucknow , Negative Blood Donor in Maharajganj, Negative Blood Donor in Mahoba, Negative Blood Donor in Mainpuri, Negative Blood Donor in Mathura , Negative Blood Donor in Mau , Negative Blood Donor in Meerut , Negative Blood Donor in Mirzapur, Negative Blood Donor in Moradabad, Negative Blood Donor in Muzaffarnagar, Negative Blood Donor in Pilibhit, Negative Blood Donor in Pratapgarh , Negative Blood Donor in RaeBareli , Negative Blood Donor in Rampur , Negative Blood Donor in Saharanpur, Negative Blood Donor in Sant Kabir Nagar, Negative Blood Donor in Sant Ravidas Nagar , Negative Blood Donor in Shahjahanpur, Negative Blood Donor in Shravasti , Negative Blood Donor in siddharthnagar , Negative Blood Donor in Sitapur, Negative Blood Donor in Sonbhadra, Negative Blood Donor in Sultanpur, Negative Blood Donor in Unnao, Negative Blood Donor in Almora , Negative Blood Donor in Bageshwar ,Negative Blood Donor in Chamoli ,Negative Blood Donor in Champawat ,Negative Blood Donor in Dehradun ,Negative Blood Donor in Haridwar ,Negative Blood Donor in Nainital ,Negative Blood Donor in Pauri, Negative Blood Donor in Garhwal ,Negative Blood Donor in Pithoragarh ,Negative Blood Donor in Rudraprayag ,Negative Blood Donor in Tehri ,Negative Blood Donor in Garhwal ,Negative Blood Donor in Udham Singh Nagar ,Negative Blood Donor in Uttarkashi , Negative Blood Donor in Chennai ,Negative Blood Donor in Coimbatore ,Negative Blood Donor in Cuddalore ,Negative Blood Donor in Dharmapuri, Negative Blood Donor in Dindigul ,Negative Blood Donor in Erode ,Negative Blood Donor in Kanchipuram ,Negative Blood Donor in Kanyakumari, Negative Blood Donor in Karur ,Negative Blood Donor in Krishnagiri, Negative Blood Donor in Madurai ,Negative Blood Donor in Nagapattinam ,Negative Blood Donor in Namakkal ,Negative Blood Donor in Nilgiris, Negative Blood Donor in Perambalur, Negative Blood Donor in Pudukkottai, Negative Blood Donor in Ramanathapuram, Negative Blood Donor in Salem ,Negative Blood Donor in Sivaganga ,Negative Blood Donor in Thanjavur ,Negative Blood Donor in Theni, Negative Blood Donor in Thoothukudi ,Negative Blood Donor in Tiruchirappalli, Negative Blood Donor in Tirunelveli ,Negative Blood Donor in Tiruvallur ,Negative Blood Donor in Tiruvannamalai ,Negative Blood Donor in Tiruvarur ,Negative Blood Donor in Vellore ,Negative Blood Donor in Viluppuram ,Negative Blood Donor in Virudhunagar,Negative Blood Donor in Aizawl , Negative Blood Donor in Champhai , Negative Blood Donor in Kolasib, Negative Blood Donor in Lawngtlai , Negative Blood Donor in Lunglei , Negative Blood Donor in Mamit, Negative Blood Donor in Saiha , Negative Blood Donor in Serchhip,Negative Blood Donor in Adilabad, Negative Blood Donor in Anantapur, Negative Blood Donor in Chittoor ,Negative Blood Donor in Cuddapah ,Negative Blood Donor in East Godavari, Negative Blood Donor in Guntur ,Negative Blood Donor in Hyderabad ,Negative Blood Donor in Karimnagar, Negative Blood Donor in Khammam ,Negative Blood Donor in Krishna ,Negative Blood Donor in Kurnool ,Negative Blood Donor in Mahabubnagar, Negative Blood Donor in Medak ,Negative Blood Donor in Nalgonda, Negative Blood Donor in Nellore, Negative Blood Donor in Nizamabad , Negative Blood Donor in Prakasam ,Negative Blood Donor in Rangareddy, Negative Blood Donor in , Negative Blood Donor in Srikakulam, Negative Blood Donor in Visakhapatnam ,Negative Blood Donor in Vizianagaram, Negative Blood Donor in Warangal ,Negative Blood Donor in West Godavari, Negative Blood Donor in Anjaw , Negative Blood Donor in Changlang , Negative Blood Donor in Dibang Valley ,Negative Blood Donor in East Kameng ,Negative Blood Donor in ,East Siang , Negative Blood Donor in Kurung Kumey , Lohit Lower , Negative Blood Donor in Dibang Valley Lower , Negative Blood Donor in Subansiri Papum Pare , Negative Blood Donor in Tawang Tirap ,Negative Blood Donor in Upper Siang , Negative Blood Donor in Upper Subansiri ,Negative Blood Donor in West Kameng , Negative Blood Donor in West Siang , Negative Blood Donor in Bagalkot ,Negative Blood Donor in Bangalore ,Negative Blood Donor in Bangalore ,Negative Blood Donor in Rural Belgaum ,Negative Blood Donor in Bellary ,Negative Blood Donor in Bidar ,Negative Blood Donor in Bijapur , Negative Blood Donor in Chamrajnagar, Negative Blood Donor in Chickmagalur, Negative Blood Donor in Chikballapur ,Negative Blood Donor in Chitradurga ,Negative Blood Donor in Dakshina ,Negative Blood Donor in Kannada ,Negative Blood Donor in Davangere ,Negative Blood Donor in Dharwad ,Negative Blood Donor in Gadag ,Negative Blood Donor in Gulbarga ,Negative Blood Donor in Hassan ,Negative Blood Donor in Haveri ,Negative Blood Donor in Kodagu ,Negative Blood Donor in Kolar Koppal, Negative Blood Donor in Mandya ,Negative Blood Donor in Mysore ,Negative Blood Donor in Raichur, Negative Blood Donor in Shimoga ,Negative Blood Donor in Tumkur ,Negative Blood Donor in Udupi ,Negative Blood Donor in Uttara Kannada
Negative Blood Donor in Amritsar , Negative Blood Donor in Barnala ,Negative Blood Donor in
Bathinda ,Negative Blood Donor in Faridkot ,Negative Blood Donor in
Fatehgarh Sahib ,Negative Blood Donor in Ferozepur ,Negative Blood Donor in Gurdaspur, Negative Blood Donor in Hoshiarpur, Negative Blood Donor in Jalandhar, Negative Blood Donor in Kapurthala ,Negative Blood Donor in Ludhiana ,Negative Blood Donor in Mansa Moga Muktsar, Negative Blood Donor in Nawanshahr ,Negative Blood Donor in Patiala ,Negative Blood Donor inRupnagar ,Negative Blood Donor in Sangrur ,Negative Blood Donor in SAS Nagar , Negative Blood Donor in Tarn Taran Negative Blood Donor in Ajmer ,Negative Blood Donor in Alwar ,Negative Blood Donor in Banswara ,Negative Blood Donor in Baran ,Negative Blood Donor in Barmer ,Negative Blood Donor in Bharatpur, Negative Blood Donor in Bhilwara ,Negative Blood Donor in Bikaner ,Negative Blood Donor in Bundi, Negative Blood Donor in Chittorgarh ,Negative Blood Donor in Churu ,Negative Blood Donor in Dausa ,Negative Blood Donor in Dholpur ,Negative Blood Donor in Dungarpur, Negative Blood Donor in Hanumangarh ,Negative Blood Donor in Jaipur, Negative Blood Donor in Jaisalmer ,Negative Blood Donor in Jalore ,Negative Blood Donor in Jhalawar ,Negative Blood Donor in Jhunjhunu ,Negative Blood Donor in Jodhpur ,Negative Blood Donor in Karauli, Negative Blood Donor in Kota ,Negative Blood Donor in Nagaur ,Negative Blood Donor in Pali ,Negative Blood Donor in Rajsamand ,Negative Blood Donor in Sawai Madhopur ,Negative Blood Donor in Sikar, Negative Blood Donor in Sirohi ,Negative Blood Donor in Sri Ganganagar, Negative Blood Donor in Tonk ,Negative Blood Donor in Udaipur Negative Blood Donor in Ahmednagar ,Negative Blood Donor in Akola ,Negative Blood Donor in Amravati ,Negative Blood Donor in Aurangabad ,Negative Blood Donor in Beed ,Negative Blood Donor in Bhandara ,Negative Blood Donor in Buldhana ,Negative Blood Donor in Chandrapur, Negative Blood Donor in Dhule , Negative Blood Donor in Gadchiroli ,Negative Blood Donor in Gondia ,Negative Blood Donor in Hingoli ,Negative Blood Donor in Jalgaon ,Negative Blood Donor in Jalna ,Negative Blood Donor in Kolhapur ,Negative Blood Donor in Latur ,Negative Blood Donor in Mumbai City ,Negative Blood Donor in Mumbai Suburban ,Negative Blood Donor in Nagpur ,Negative Blood Donor in Nanded ,Negative Blood Donor in Nandurbar ,Negative Blood Donor in Nashik ,Negative Blood Donor in Osmanabad ,Negative Blood Donor in Parbhani ,Negative Blood Donor in Pune ,Negative Blood Donor in Raigad ,Negative Blood Donor in Ratnagiri ,Negative Blood Donor in Sangli ,Negative Blood Donor in Satara ,Negative Blood Donor in Sindhudurg ,Negative Blood Donor in Solapur ,Negative Blood Donor in Thane ,Negative Blood Donor in Wardha ,Negative Blood Donor in Washim ,Negative Blood Donor in Yavatmal Negative Blood Donor in Ahmedabad ,Negative Blood Donor in Amreli ,Negative Blood Donor in Anand ,Negative Blood Donor in Banaskantha ,Negative Blood Donor in Bharuch, Negative Blood Donor in Bhavnagar, Negative Blood Donor in Dahod ,Negative Blood Donor in Dang, Negative Blood Donor in Gandhinagar ,Negative Blood Donor inJamnagar ,Negative Blood Donor in Junagadh ,Negative Blood Donor in Kheda ,Negative Blood Donor in Kutch ,Negative Blood Donor in Mehsana, Negative Blood Donor in Narmada ,Negative Blood Donor in Navsari ,Negative Blood Donor in Panchmahals, Negative Blood Donor in Patan, Negative Blood Donor in Porbandar, Negative Blood Donor in Rajkot, Negative Blood Donor in Sabarkantha, Negative Blood Donor in Surat ,Negative Blood Donor in Surendranagar, Negative Blood Donor in Vadodara ,Negative Blood Donor in ValsadNegative Blood Donor in Bankura, Negative Blood Donor in Bardhaman ,Negative Blood Donor in Birbhum ,Negative Blood Donor in Cooch Behar, Negative Blood Donor in Darjeeling East, Negative Blood Donor in Medinipur ,Negative Blood Donor in Hooghly, Negative Blood Donor in Howrah ,Negative Blood Donor in Jalpaiguri ,Negative Blood Donor in Malda ,Negative Blood Donor in Murshidabad ,Negative Blood Donor in Nadia North ,Negative Blood Donor in 24 Parganas ,Negative Blood Donor in North Dinajpur, Negative Blood Donor in Purulia ,Negative Blood Donor in South 24 Parganas ,Negative Blood Donor in South Dinajpur ,Negative Blood Donor in West Medinipur ,Negative Blood Donor in Bankura Bardhaman ,Negative Blood Donor

Are you Negative Blood Donor in Himachal Pradesh India , Please Join RareBloodGroups.Org

Are you Negative Blood Donor in India , Please Join RareBloodGroups.Org

PLEASE VISIT WWW.RAREBLOODGROUPS.ORG


Imagine some unfortunate disaster happen here in the city like Earth Quakes in Gujrat and Kashmir or any other . Are we ready of face the same .


We have started a new support group for RH Negative Blood Types & Rare Blood Groups.


Rare Blood is just like all other Blood, and will not cause you any problem at all unless you need a transfusion.

The goal of the our new website RareBloodGroups.Org is to maintain an up-to-date registry of all donors with rare blood types i.e AB Negative Blood , B Negative Blood, O Negative Blood, A Negative Blood and Bombay Blood Group so that any patient in need can quickly be transfused with blood that is safe for him or her.

Please visit this website at

http://www.rarebloodgroups.org

Himachal Pradesh

Bilaspur Chamba Hamirpur Kangra Kinnaur Kullu Lahaul & Spiti Mandi Shimla Sirmaur Solan Una

Negative Blood Donor in Bilaspur , Negative Blood Donor in Chamba , Hamirpur , Negative Blood Donor in Kangra , Negative Blood Donor in Kinnaur, Negative Blood Donor in Kullu , Negative Blood Donor in Lahaul & Spiti , Negative Blood Donor in Mandi, Negative Blood Donor in Shimla Negative Blood Donor in Sirmaur , Negative Blood Donor in Solan , Negative Blood Donor in Una

Are you Negative Blood Donor in Andhra Pradesh India , Please Join RareBloodGroups.Org

Are you Negative Blood Donor in Andhra Pradesh India , Please Join RareBloodGroups.Org



PLEASE VISIT WWW.RAREBLOODGROUPS.ORG



Imagine some unfortunate disaster happen here in the city like Earth Quakes in Gujrat and Kashmir or any other . Are we ready of face the same .





We have started a new support group for RH Negative Blood Types & Rare Blood Groups.





Rare Blood is just like all other Blood, and will not cause you any problem at all unless you need a transfusion.



The goal of the our new website RareBloodGroups.Org is to maintain an up-to-date registry of all donors with rare blood types i.e AB Negative Blood , B Negative Blood, O Negative Blood, A Negative Blood and Bombay Blood Group so that any patient in need can quickly be transfused with blood that is safe for him or her.



Please visit this website at



http://www.rarebloodgroups.org








Marjor Districts and Towns where we are looking for Rh Negative Blood Donors i.e AB Negative Blood , B Negative Blood, O Negative Blood, A Negative Blood and Bombay Blood Group ( Rare Blood Groups )

Adilabad Anantapur Chittoor Cuddapah East Godavari Guntur Hyderabad Karimnagar Khammam Krishna Kurnool Mahabubnagar Medak Nalgonda Nellore Nizamabad Prakasam Rangareddy Srikakulam Visakhapatnam Vizianagaram Warangal West Godavari Negative Blood Donor in Adilabad, Negative Blood Donor in Anantapur, Negative Blood Donor in Chittoor ,Negative Blood Donor in Cuddapah ,Negative Blood Donor in East Godavari, Negative Blood Donor in Guntur ,Negative Blood Donor in Hyderabad ,Negative Blood Donor in Karimnagar, Negative Blood Donor in Khammam ,Negative Blood Donor in Krishna ,Negative Blood Donor in Kurnool ,Negative Blood Donor in Mahabubnagar, Negative Blood Donor in Medak ,Negative Blood Donor in Nalgonda, Negative Blood Donor in Nellore, Negative Blood Donor in Nizamabad , Negative Blood Donor in Prakasam ,Negative Blood Donor in Rangareddy, Negative Blood Donor in , Negative Blood Donor in Srikakulam, Negative Blood Donor in Visakhapatnam ,Negative Blood Donor in Vizianagaram, Negative Blood Donor in Warangal ,Negative Blood Donor in West Godavari,

What is Bombay Blood Group ?Rare Blood Group “Bombay (Oh) Phenotype : RareBloodGroups.Org

Of the hereditary conditions of blood, theblood group serology plays an important role inthe transfusion medicine. The discovery of a rareblood group, “Bombay phenotype” in threeunrelated individuals in Mumbai (formerlyBombay) by Bhende et al. (1952) was importantin the field of immunohematology. The discoverylater helped Watkins and Morgan (1959) andGerard et al. (1982) to elucidate biosyntheticpathway for ABH and Lewis (Le) antigens,suggesting that secretor (Se) and H are closelylinked structural genes. Recently, moleculargenetics studies were carried out to determinethe role of the H, Se, and Le genes in theexpression of H antigen in secretions and Lewisblood group antigen on erythrocytes (Kanekoet al. 1997; Oriol et al. 2000).It is important to be cautious in predictingthe ABO blood type of children based on thephenotypes of their parents. This is due to thefact that a third antigen (H) on the surface of redcells can prevent the expected ABO blood typefrom occurring. Normally, if an A blood typemother has an O type child, the father is expectedto be type O or at least to carry the O allele (OO,AO, or BO genotype). The child has inherited anO allele from both parents. However, an O bloodtype child can also be born to parents who donot have the O allele if a recessive form of theallele for the H antigen also is inherited from bothparents.

The H antigen is a precursor to the Aand B antigens. For instance, the B allele must bepresent to produce the B enzyme that modifiesthe H antigen to become the B antigen. It is alsotrue for the A allele. However, if only recessivealleles for the H antigen are inherited (hh), the Hantigen will not be produced. Subsequently, theA and B antigens also will not be produced. Theresult is an O phenotype by default since thelack of A and B antigens is the O type. Thisimpossible phenotype has been referred to as aBombay (Oh) phenotype.The present study was designed with thefollowing objectives: i). To detect and identifythe rare blood groups like Bombay (Oh)phenotype, if any in the tribes of Orissa; ii).Todiscuss the data on Bombay phenotype in thelight of earlier studies from India.BOMBAY PHENOTYPEThe gene interactions come across instanceswhere a novel phenotype does not appear butan effect caused by one gene pair interferes withor hides an effect caused by another gene pair.This type of interaction is called epistasis andmay be considered the counterpart of dominancerelations between alleles (when one allelemodifies or hides the effect of another allele atthe same gene pair). Epistasis may be caused bythe presence of homozygous recessives at onegene pair. This pattern of epistatic interactioncan also be seen in humans, where theappearance of detectable ABO blood typeantigens has been shown to depend upon thepresence of H gene. The ABO gene is located onchromosome 9(9q34.1). The other traitsassociated with genes on chromosome 9 aregalactosemia, nail-patella syndrome, andxeroderma pigmentosa. An individual who ishomozygous for the very rare recessive h allele,shows no such antigens and is phenotypicallyof blood type O (Bombay phenotype). The Hgene is responsible for the attachment of certainsubterminal sugars to those polysaccharidesupon which the terminal sugars attach themselvesas specified by the ABO genes. Thus, homo-zygous (hh) individuals lack the polysaccharideorganisation for terminal sugar attachment and,therefore, appear to lack ABO blood typeantigens, although they do not lack ABO genes(Strickberger 1999).The existence of a human H/h geneticpolymorphism was first established by thediscovery in India (Bombay) of an individualdevoid of the H antigen on red cells, who hadantibodies in plasma reacting with all the cellsexhibiting the normal red cell ABO phenotypes(Bhende et al. 1952). However, this H deficient orBombay phenotype was rare, since it occurred inabout one in 10,000 individuals in India and oneper one million individuals in Europe. Morerecently, a large series of H deficient individuals(~1:1000) was found in a small French Island 800kmeast of Madagascar, in the Indian Ocean, calledReunion Island (Le Pendu et al. 1983). Two distinctphenotypes were found, the classical Bombayphenotype among Tamoul Indian immigrantfamilies and a new, partially deficient phenotype,called the “Reunion” phenotype. The twophenotypes resulted from products, or lack ofproducts, of two different alleles of FUT1 andFUT2 genes (Le Pendu et al. 1983 ); the same andalso additional alleles of both FUT1 and FUT2were documented in other populations,particularly, in Japan, where the incidence ofBombay and para-Bombay individuals wasshown to be 1-2 in 300,000 (Kaneko et al. 1997).In Taiwan, para-Bombay phenotype has afrequency of 1:8000 (Yu et al. 1997).The mutational analysis has revealed that theBombay phenotype fails to express the ABHantigens of ABO blood group system on redblood cells and in secretions because of a lack inactivities of the H gene (FUT1)- and Secretorgene (FUT2)-encoded alpha (1,2) fucosyl-transferases (Koda et al. 1997). In this study, theyexamined the FUT1 and the FUT2 from threeunrelated Indian individuals with the Bombayphenotype and found to be homozygous for aT725G mutation in the coding region of the FUT1,which inactivated the enzyme activity. Further,they could not detect any hybridized bandcorresponding to the FUT2 by Southern blotanalysis using the catalytic domain of the FUT2as probe, indicating that the three individualswere homozygous for a gene deletion in the FUT2.These results suggested that the T725G mutationof FUT1 and the gene deletion of FUT2 areresponsible for the classical Indian Bombayphenotype. Later studies (Fernandez-Mateos etal. 1998) have pointed out that the Indian red cellH null Bombay phenotype depends on a newmutation of the FUT1 gene, i.e. T725G changingLeu242→Arg. Their salivary nonsecretorphenotype is secondary to a complete deletionof the FUT2 gene. The red cell H weak Reunionphenotype depends on another new mutation ofFUT1, C349→T, which induces a change ofHis117→Tyr. Their salivary nonsecretorphenotype is due to the known Caucasianinactivating mutation G428→A (Fernandez-Mateos et al. 1998).There is the possibility of linkage disequili-brium of FUT1 and FUT2 genes. The two geneslie in close proximity on chromosome 19q13.3.There is co-existence of unique sets of mutationsin FUT1 and FUT2, each set occurring inindividuals of a certain ethnic group. Thus inIndia, the FUT1 mutation 725T>G travels almostalways (one exception) with a total deletion ofFUT2; in Reunion Island (Caucasian), the majorinactivating mutation of FUT1 or 349C>T, travelsalmost always with the inactivating mutation ofFUT2 or 428G>A; and the main Orientalinactivating mutations of FUT1 travel almostalways with the wild type FUT2 (Fernandez-Mateos et al. 1998).After the first report of Oh phenotype fromMumbai (formerly Bombay) in 1952 by Bhendeand coworkers, several other workers detectedthis peculiar phenotype in India (Simmons andD’senna 1955; Roy et al. 1957) and also in theEuropean countries (Alosia et al. 1961; Aust etal. 1962). Later on, it was found that many of theEuropean cases, which were initially labelled astypical Bombay phenotypes, turned out to bepara Bombay phenotypes after absorption elution
The most striking finding of the present studywas the detection of two unrelated cases ofBombay (Oh) phenotype in the primitive tribe,Kutia Kondh from the Belghar area of Phulbanidistrict in Orissa. No case of Bombay phenotypehas ever been reported among the primitive tribesfrom the state of Orissa and this is the first suchreport from Central East part of India. Thedifficulty in Bombay phenotype is that theindividual having blood group of Bombayphenotype (Oh) can only receive blood from anindividual of Bombay phenotype and no otherblood will match in case of an emergency forblood transfusion.The present study shows an incidence ofBombay phenotype 1 in 33 among the KutiaKondh tribe, 1 in 127 among Kondh tribe and 1 in1,244 among the tribal populations of Orissa.Since the population size of Kutia Kondh tribewas relatively small (around 5000 individuals) andthe practice of endogamy is strictly followed,therefore, the inbreeding and consanguinityamongst them is not ruled out which may be oneof the major factors for the combination ofrecessive rare alleles like Bombay phenotypeamong the Kutia Kondh tribe. Bhatia and Sanghvi(1962) calculated the incidence of this phenotypeFig.1. Map of India showing different statesas 1 in 13000 individuals in Mumbai. Later on,Bhatia and Sathe (1974) found its incidence as 1in 7600 after screening a large number of samplesin Mumbai. Gorakshakar et al. (1987) aftersystematic screening of the rural population fromRatnagiri and Sindhudurg districts ofMaharashtra reported the incidence of Bombayphenotype as 1 in 4500 in that region, whileMoores (1980) found its incidence as 1 in 18404amongst Indians settled in South Africa.Regarding the distribution and spread ofBombay phenotype in different states of India,the Oh phenotype is more common in state ofWestern and Southern parts of India as comparedto other states (Fig. 1). Of the 179 cases reportedby Sathe et al. (1988) from the Institute ofImmunohematology (formerly Blood GroupReference Centre, Bombay), Mumbai, 112 (62.6%)cases belonged to the state of Maharashtra alone.The frequency was also high in Karnataka (14cases), Andhra Pradesh (8 cases), Goa (6 cases),Gujarat (5 cases), Uttar Pradesh (5 cases) and soon in the decreasing order.The incidence ofBombay phenotype is high in those states ofIndia where the consanguineous marriages aremore prevalent, i.e. Andhra Pradesh, Tamil Nadu,Karnataka, Maharashtra, Gujarat, etc. than theother states The Bombay phenotypes were also detectedin Japan (Okubo 1980; Kaneko et al. 1997),Malaysia (Lopez, 1972), Thailand (Sringarm et al.1977) and Sri Lanka (De Zoysa 1985). Yunis et al.(1969) found seven individuals of Oh phenotypein two generations in an Indian family settled inthe USA. They were the natives of Orissa state.Similarly, Moores (1980) found 24 cases of Ohphenotypes in eleven unrelated Indian familiessettled in Natal, South Africa. Most of thesefamilies were either Tamil or Telugu speaking.Therefore, their origin presumed to be AndhraPradesh or Tamil Nadu. This indicates that theBombay phenotype is mostly confined to South-East Asian countries.Further molecular and mutational research isrequired on Bombay phenotype regarding theevolutionary significance and the operation ofnatural selection among the Kutia Kondhprimitive tribe of India.

To Register Youself a Bombay Blood Type or Any Rare Blood Type , Please visit www.rarebloodgroups.org

How rare is your rarest blood group? AB -ve , B -ve , O -ve or A -ve ?

Blood donors are needed throughout the year. However, the need is felt more in the case of rare blood groups such as B negative, AB positive and AB negative. If the statistics available are any indication, it will send jitters. According to information available, the approximate
distribution of blood types universally is: O Rh-positive 38%, O Rh-negative 7%, A Rh-positive 34%, A Rh-negative 6%, B Rh-positive 9%, B Rh-negative 2%, AB Rh-positive 3% and AB Rh-negative 1%. However, the specific distribution may be different for specific racial and ethnic groups.

Given the scale of distribution of blood groups one can easily find out the number of people of particular blood type living in twin cities. Twin cities with a population of 60 lakh people (on conservative note) have approximately 22.8 lakh O Rh-positive, 4.2 lakh O Rh-negative, 20.4 lakh A Rh-positive, 3.6 lakh A Rh-negative, 5.4 lakh B Rh-positive, 1.2 lakh B Rh-negative, 1.8 lakh AB Rh-positive and 0.6 lakh AB Rh-negative blood type people.

What if some patients urgently require blood types found in only one in one hundred donors? Especially in case of heart surgeries each patient needs 6 units of blood.

The very thought of such situation is very scary. Because of this reason, Now We are trying their best to identify donors who have these rare blood types and ask them to enlist Rare Blood Donors Website , ( www.rarebloodgroups.org ) a free service which family members of the patients can utilise when they need voluntary blood donors for emergency surgeries. Such donors can give their personal details such as Name, Blood Group, address, contact telephone, mobile number and email